Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17465774 | 0.87 | NTRK1 (0.41) | JAK2NTRK1FLT3PIM1PIM2 | |
| SCHEMBL16120069 | 0.77 | PRMT1 (0.42) | JAK2NTRK1FLT3CDK1CDK4 | |
| SCHEMBL16120049 | 0.77 | PRMT5 (0.48) | — | |
| SCHEMBL17457591 | 0.76 | NTRK1 (0.41) | JAK2NTRK1FLT3CDK1CDK4 | |
| SCHEMBL14487030 | 0.72 | JAK2 (0.59) | JAK2NTRK1MAP4K4ARIP6K1 | |
| SCHEMBL16119983 | 0.70 | KDM4E (0.37) | HSD17B10 | |
| SCHEMBL16119991 | 0.69 | TRPM8 (0.48) | NTRK1FLT3 | |
| SCHEMBL24172742 | 0.68 | JAK2 (0.45) | JAK2NTRK1ARFGFR1DYRK1A | |
| SCHEMBL16119960 | 0.65 | PRMT1 (0.46) | — | |
| SCHEMBL17469510 | 0.63 | PRMT1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153235-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |