Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 8/20 | 0.42 |
| ▸ | EGFR | P00533 | 7/20 | 0.41 |
| ▸ | BCL6 | P41182 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320846 | 0.94 | TBK1 (0.48) | TBK1EGFRJAK2 | |
| SCHEMBL15321086 | 0.94 | TBK1 (0.42) | TBK1EGFRCSNK2A2CSNK2A1JAK2 | |
| SCHEMBL15321087 | 0.94 | TBK1 (0.42) | TBK1EGFRCSNK2A2CSNK2A1JAK2 | |
| SCHEMBL15320389 | 0.94 | TBK1 (0.42) | TBK1EGFRCSNK2A2CSNK2A1JAK2 | |
| SCHEMBL15321782 | 0.92 | EGFR (0.48) | TBK1EGFRJAK2ITK | |
| SCHEMBL15321372 | 0.92 | EGFR (0.48) | TBK1EGFRJAK2ITK | |
| SCHEMBL15321376 | 0.92 | EGFR (0.48) | TBK1EGFRJAK2ITK | |
| SCHEMBL15320723 | 0.88 | EGFR (0.53) | EGFRBTKITK | |
| SCHEMBL19527674 | 0.88 | EGFR (0.46) | EGFRBCL6BTKITKPRKCQ | |
| SCHEMBL15320611 | 0.88 | EGFR (0.46) | EGFRBCL6BTKITKPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014151900-A1 | PROTEIN KINASE C INHIBITORS AND USES THEREOF | RIGEL PHARMACEUTICALS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |