Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613297 | 0.86 | PTK2 (0.51) | LRRK2PTK2EGFRALKTTK | |
| SCHEMBL1612485 | 0.86 | LRRK2 (0.52) | LRRK2PTK2EGFR | |
| SCHEMBL1613415 | 0.79 | PTK2 (0.61) | LRRK2PTK2EGFRALKERBB2 | |
| SCHEMBL4392385 | 0.78 | LRRK2 (0.54) | LRRK2ALKTTK | |
| SCHEMBL1612742 | 0.77 | PTK2 (0.53) | LRRK2PTK2EGFRALKERBB2 | |
| SCHEMBL1612345 | 0.74 | PTK2 (0.47) | LRRK2PTK2ALK | |
| SCHEMBL1613293 | 0.73 | PTK2 (0.55) | LRRK2PTK2EGFRALK | |
| SCHEMBL1613386 | 0.73 | PTK2 (0.65) | LRRK2PTK2EGFRALKERBB2 | |
| SCHEMBL2031313 | 0.73 | PTK2 (0.48) | LRRK2PTK2ALK | |
| SCHEMBL13895958 | 0.73 | PTK2 (0.62) | LRRK2PTK2ALKTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086842-A1 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-04-14 | — | — | US | disclosed |
| US-20090163465-A1 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-25 | — | — | US | disclosed |
| US-20090149438-A1 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163465-A1 | Pyrimidines as PLK inhibitors | PLK2, PLK3, TYMP | LRRK2 1725/4885PTK2 833/4885EGFR 2739/4885 |
| US-20110086842-A1 | Pyrimidines as PLK inhibitors | PLK2, PLK3, TYMP | LRRK2 1725/4885PTK2 833/4885EGFR 2739/4885 |
| US-20090149438-A1 | Pyrimidines as PLK inhibitors | PLK2, PLK3, TYMP | LRRK2 1725/4885PTK2 833/4885EGFR 2739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.