Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR1B | O00238 | 1/20 | 0.86 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.86 |
| ▸ | STK16 | O75716 | 1/20 | 0.86 |
| ▸ | STK10 | O94804 | 1/20 | 0.86 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.86 |
| ▸ | RET | P07949 | 1/20 | 0.86 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.86 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.86 |
| ▸ | PRKCA | P17252 | 1/20 | 0.86 |
| ▸ | DCK | P27707 | 1/20 | 0.86 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.86 |
| ▸ | FLT3 | P36888 | 1/20 | 0.86 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.86 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.86 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.86 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.86 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.86 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.86 |
| ▸ | CLK3 | P49761 | 1/20 | 0.86 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16117323 | 0.93 | BMPR1B (1.00) | BMPR1BRIPK2STK16STK10MAP4K4 | |
| SCHEMBL7901532 | 0.90 | MTOR (1.00) | BMPR1BRIPK2STK16STK10MAP4K4 | |
| SCHEMBL13828403 | 0.86 | BMPR1B (0.64) | BMPR1BRIPK2STK16STK10MAP4K4 | |
| Sapanisertib SCHEMBL29351459 | 0.83 | MTOR (1.00) | BMPR1BRIPK2STK16STK10MAP4K4 | |
| Sapanisertib SCHEMBL7902875 | 0.83 | MTOR (1.00) | BMPR1BRIPK2STK16STK10MAP4K4 | |
| SCHEMBL7894772 | 0.83 | MTOR (0.71) | BMPR1BRIPK2STK16STK10MAP4K4 | |
| SCHEMBL16117324 | 0.82 | BMPR1B (0.80) | BMPR1BRIPK2STK16STK10MAP4K4 | |
| SCHEMBL3610515 | 0.80 | SRC (1.00) | BMPR1BRIPK2STK16STK10MAP4K4 | |
| SCHEMBL14574574 | 0.79 | SRC (0.80) | MTORPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19299482 | 0.79 | MTOR (0.77) | BMPR1BRIPK2STK16STK10MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153509-A1 | COMBINATION OF CATALYTIC MTORC 1/2 INHIBITORS AND SELECTIVE INHIBITORS OF AURORA A KINASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |