Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.53 |
| ▸ | YES1 | P07947 | 5/20 | 0.53 |
| ▸ | FGR | P09769 | 5/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.50 |
| ▸ | FYN | P06241 | 4/20 | 0.50 |
| ▸ | LYN | P07948 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 9/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | FRK | P42685 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.46 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | HCK | P08631 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902941 | 0.78 | SRC (0.56) | SRCYES1FGRPIK3CGPIK3CA | |
| SCHEMBL15613596 | 0.77 | SRC (0.65) | SRCYES1FGRPIK3CGPIK3CA | |
| SCHEMBL20132621 | 0.70 | SRC (1.00) | SRCYES1FGRFYNLYN | |
| SCHEMBL12422345 | 0.70 | PIK3CD (0.66) | SRCYES1FGRPIK3CGPIK3CA | |
| SCHEMBL2965908 | 0.69 | IGF1R (0.71) | EGFR | |
| SCHEMBL18250084 | 0.67 | SRC (1.00) | SRCYES1FGRFYNLYN | |
| SCHEMBL22539896 | 0.67 | YES1 (0.42) | SRCYES1FGRFYNLYN | |
| SCHEMBL18258327 | 0.67 | SRC (0.73) | SRCYES1FGRPIK3CGPIK3CA | |
| SCHEMBL16886171 | 0.66 | SRC (0.50) | SRCYES1FGRPIK3CAFYN | |
| SCHEMBL16712875 | 0.66 | PIK3CD (0.72) | SRCPIK3CGPIK3CAABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153509-A1 | COMBINATION OF CATALYTIC MTORC 1/2 INHIBITORS AND SELECTIVE INHIBITORS OF AURORA A KINASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |