Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.72 |
| ▸ | PRKDC | P78527 | 16/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.55 |
| ▸ | EGFR | P00533 | 11/20 | 0.55 |
| ▸ | SRC | P12931 | 11/20 | 0.55 |
| ▸ | ABL1 | P00519 | 10/20 | 0.55 |
| ▸ | HCK | P08631 | 10/20 | 0.55 |
| ▸ | MTOR | P42345 | 10/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.55 |
| ▸ | KDR | P35968 | 9/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ITK | Q08881 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16701439 | 0.84 | PIK3CD (1.00) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL16701549 | 0.78 | PIK3CD (0.75) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL130637 | 0.78 | PIK3CD (0.81) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL23917452 | 0.77 | PIK3CD (0.55) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL16702256 | 0.76 | EGFR (0.61) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL16701525 | 0.75 | PIK3CD (0.58) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL16701652 | 0.74 | EGFR (0.51) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL16701979 | 0.74 | EGFR (0.58) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL16701967 | 0.74 | PIK3CD (0.66) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB | |
| SCHEMBL22276020 | 0.73 | PIK3CD (0.47) | PIK3CDPRKDCPIK3CAPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015069441-A1 | PYRAZOLO-, IMIDAZOLO- AND PYRROLO-PYRIDINE OR -PYRIMIDINE DERIVATIVES AS INHIBITORS O BRUTONS KINASE (BTK) | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-05-14 | — | — | WO | disclosed |