Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 3/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.53 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.53 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.53 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.53 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.49 |
| ▸ | MAP3K14 | Q99558 | 5/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.44 |
| ▸ | CDC7 | O00311 | 5/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1613551 | 0.90 | PAK4 (0.55) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL1613483 | 0.87 | MAP3K14 (0.48) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL1613405 | 0.83 | MAP3K14 (0.44) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL24153194 | 0.82 | CDC7 (0.60) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12742513 | 0.82 | ROCK1 (0.49) | TTBK1MAP3K14ROCK1CDC7CDK2 | |
| SCHEMBL1613992 | 0.82 | PAK4 (0.46) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL28688403 | 0.79 | CDC7 (0.62) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL24152424 | 0.78 | PAK4 (0.55) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL24153382 | 0.76 | PAK4 (0.53) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL24153373 | 0.76 | PAK4 (0.51) | PAK4PAK1PAK2PKN1PAK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315751-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | Amgen Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | PAK4 323/4885PAK1 144/4885PAK2 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.