Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLLT1 | Q03111 | 1/20 | 0.64 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | PYGL | P06737 | 1/20 | 0.54 |
| ▸ | PYGM | P11217 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534668 | 0.89 | DRD4 (0.58) | MLLT1SMYD3MEN1KMT2ARAB9A | |
| SCHEMBL3608213 | 0.87 | MLLT1 (0.53) | MLLT1SMYD3HDAC3HDAC1HDAC2 | |
| SCHEMBL3607417 | 0.87 | MLLT1 (0.53) | MLLT1SMYD3HDAC3HDAC1HDAC2 | |
| SCHEMBL3607418 | 0.87 | MLLT1 (0.53) | MLLT1SMYD3HDAC3HDAC1HDAC2 | |
| SCHEMBL3603886 | 0.84 | HRH4 (0.56) | MLLT1SMYD3HDAC3HDAC1HDAC2 | |
| SCHEMBL3603891 | 0.84 | HRH4 (0.56) | MLLT1SMYD3HDAC3HDAC1HDAC2 | |
| SCHEMBL3613025 | 0.84 | HRH4 (0.56) | MLLT1SMYD3HDAC3HDAC1HDAC2 | |
| SCHEMBL29176327 | 0.83 | MLLT1 (0.61) | MLLT1SMYD3HDAC1HDAC6RAB9A | |
| SCHEMBL20535296 | 0.83 | MLLT1 (0.57) | MLLT1SMYD3HDAC1HDAC6MEN1 | |
| SCHEMBL1156082 | 0.83 | SMYD3 (0.67) | MLLT1SMYD3HDAC2FLT3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2011-04-14 | — | — | US | disclosed |
| WO-2009158011-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | AMGEN INC. (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086834-A1 | ALKYNYL ALCOHOLS AS KINASE INHIBITORS | NFKBIA, MAP3K1, MAP3K2 | MLLT1 1461/4885SMYD3 2756/4885HDAC3 737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.