Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLLT1 | Q03111 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29176327 | 0.97 | MLLT1 (0.61) | MLLT1DRD4SMYD3RAB9ANPC1 | |
| SCHEMBL29176357 | 0.96 | MLLT1 (0.60) | MLLT1DRD4SMYD3RAB9ANPC1 | |
| SCHEMBL18183271 | 0.96 | MLLT1 (0.60) | MLLT1DRD4SMYD3RAB9ANPC1 | |
| SCHEMBL20534668 | 0.94 | DRD4 (0.58) | MLLT1DRD4SMYD3RAB9AHRH4 | |
| SCHEMBL3612493 | 0.88 | DRD4 (0.50) | MLLT1DRD4HRH4 | |
| SCHEMBL3612490 | 0.88 | DRD4 (0.50) | MLLT1DRD4HRH4 | |
| SCHEMBL3599033 | 0.85 | DRD4 (0.52) | MLLT1DRD4SMYD3HRH4KDR | |
| SCHEMBL3599029 | 0.85 | DRD4 (0.52) | MLLT1DRD4SMYD3HRH4KDR | |
| SCHEMBL3599027 | 0.85 | DRD4 (0.52) | MLLT1DRD4SMYD3HRH4KDR | |
| SCHEMBL1613614 | 0.83 | MLLT1 (0.64) | MLLT1SMYD3RAB9AHRH4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115785100-B | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2025-01-07 | — | — | CN | claimed |
| US-20250243202-A1 | Compounds Useful as RET Inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2025-07-31 | — | — | US | disclosed |
| CN-115785100-B | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2025-01-07 | — | — | CN | disclosed |
| US-20240132504-A1 | Compounds Useful as RET Inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-04-25 | — | — | US | disclosed |
| US-11680068-B2 | Compounds useful as RET inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-06-20 | — | — | US | disclosed |
| US-11680068-B2 | Compounds useful as RET inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-06-20 | — | — | US | disclosed |
| US-11680068-B2 | Compounds useful as RET inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2023-06-20 | — | — | US | disclosed |
| CN-115785100-A | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2023-03-14 | — | — | CN | disclosed |
| EP-4105219-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS RET INHIBITORS | Cancer Research Technology Limited (GB) | 2022-12-21 | — | — | EP | disclosed |
| EP-4105219-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS RET INHIBITORS | Cancer Research Technology Limited (GB) | 2022-12-21 | — | — | EP | disclosed |
| US-20220348585-A1 | Compounds Useful as RET Inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-11-03 | — | — | US | disclosed |
| CN-110506043-B | Compounds useful as RET inhibitors | 癌症研究科技有限公司 | 2022-11-01 | — | — | CN | disclosed |
| US-11352361-B2 | Compounds useful as RET inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-06-07 | — | — | US | disclosed |
| US-11352361-B2 | Compounds useful as RET inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-06-07 | — | — | US | disclosed |
| EP-3609898-B1 | COMPOUNDS USEFUL AS RET INHIBITORS | CANCER RESEARCH TECH LTD (GB) | 2022-06-01 | — | — | EP | disclosed |
| EP-3609898-B1 | COMPOUNDS USEFUL AS RET INHIBITORS | CANCER RESEARCH TECH LTD (GB) | 2022-06-01 | — | — | EP | disclosed |
| US-20200157107-A1 | Compounds Useful as RET Inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2020-05-21 | — | — | US | disclosed |
| US-20200157107-A1 | Compounds Useful as RET Inhibitors | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2020-05-21 | — | — | US | disclosed |
| EP-3609898-A1 | COMPOUNDS USEFUL AS RET INHIBITORS | Cancer Research Technology Limited (GB) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018189553-A1 | COMPOUNDS USEFUL AS RET INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250243202-A1 | Compounds Useful as RET Inhibitors | RET, BCR, REL | MLLT1 102/4885DRD4 1570/4885SMYD3 1164/4885 |
| US-20220348585-A1 | Compounds Useful as RET Inhibitors | RET, BCR, REL | MLLT1 102/4885DRD4 1570/4885SMYD3 1164/4885 |
| US-11352361-B2 | Compounds useful as RET inhibitors | RET, BCR, REL | MLLT1 102/4885DRD4 1570/4885SMYD3 1164/4885 |
| US-20200157107-A1 | Compounds Useful as RET Inhibitors | RET, BCR, REL | MLLT1 102/4885DRD4 1570/4885SMYD3 1164/4885 |
| US-20240132504-A1 | Compounds Useful as RET Inhibitors | RET, BCR, REL | MLLT1 102/4885DRD4 1570/4885SMYD3 1164/4885 |
| US-11680068-B2 | Compounds useful as RET inhibitors | RET, BCR, REL | MLLT1 102/4885DRD4 1570/4885SMYD3 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.