Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Repaglinide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 known ✓ | Q09428 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | ABCC2 | Q92887 | 1/20 | 1.00 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Repaglinide SCHEMBL29373506 | 1.00 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL29392295 | 1.00 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL8141950 | 1.00 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL29598841 | 1.00 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL1536902 | 1.00 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL163867 | 1.00 | ABCC8 (1.00) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL6240747 | 0.99 | ABCC8 (0.98) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL29085555 | 0.99 | ABCC8 (0.98) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL6240755 | 0.99 | ABCC8 (0.98) | ABCC8LMNAMAPK1CYP3A4SLC22A1 | |
| Repaglinide SCHEMBL27961819 | 0.99 | ABCC8 (0.98) | ABCC8LMNAMAPK1CYP3A4SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 36507 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260124282-A1 | DECORIN FOR ITS USE IN THE TREATMENT OF DIABETES | CENTRE EUROPEEN D'ETUDE DU DIABETE (FR) | 2026-05-07 | — | — | US | claimed |
| US-20260115210-A1 | METHOD FOR TREATING SUBJECTS SUFFERING FROM CENTRAL NERVOUS SYSTEM CONTUSIONS | REMEDY PHARMACEUTICALS, INC. (US) | 2026-04-30 | — | — | US | claimed |
| US-12611416-B2 | Methods of treating ischemic stroke at risk for cerebral or cerebellar edema | REMEDY PHARMACEUTICALS, INC. (US) | 2026-04-28 | — | — | US | claimed |
| US-12599564-B2 | Antidiabetic pharmaceutical compositions | Elite Pharmaceutical Solution Inc. (US) | 2026-04-14 | — | — | US | claimed |
| US-20260097039-A1 | METHODS FOR TREATING A FATTY LIVER DISEASE | MADRIGAL PHARMACEUTICALS INC (US) | 2026-04-09 | — | — | US | claimed |
| US-20260085061-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2026-03-26 | — | — | US | claimed |
| US-20260069550-A1 | TRANSDERMAL DELIVERY OF ANTIDIABETIC AGENTS | RITTENHOUSE CHRISTINE (US) | 2026-03-12 | — | — | US | claimed |
| EP-4705280-A1 | DIARYL UREA-BASED COMPOUNDS AND RELATED COMPOSITIONS AND METHODS OF USE IN THE TREATMENT OF DIABETES MELLITUS AND NEURODEGENERATIVE DISEASE | Purdue Research Foundation (US) | 2026-03-11 | — | — | EP | claimed |
| EP-4684799-A2 | ANTIBODIES THAT DISRUPT THE INTERACTION OF GAL3 AND INSULIN RECEPTOR OR INTEGRINS AND METHODS OF USE THEREOF | TrueBinding, Inc. (US) | 2026-01-28 | — | — | EP | claimed |
| US-12527754-B2 | Methods and compositions for preventing and treating metabolic syndrome induced by antipsychotic treatment and related diseases and conditions | TUFTS MEDICAL CENTER, INC. (US) | 2026-01-20 | — | — | US | claimed |
| EP-0589874-B1 | USE OF (S)(+)-2-ETHOXY-4-[N-[1-(2-PIPERIDINOPHENYL)-3-METHYL-1-BUTYL]AMINOCARBONYLMETHYL]BENZOIC ACID FOR THE PREPARATION OF A LONGLASTING ANTIDIABETIC MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-09-08 | — | — | EP | claimed |
| WO-1999043708-A1 | GLP-1 DERIVATIVES OF GLP-1 AND EXENDIN WITH PROTRACTED PROFILE OF ACTION | NOVO NORDISK A/S (DK) | 1999-09-02 | — | — | WO | claimed |
| WO-1999003478-A1 | TREATMENT OF DIABETES WITH THIAZOLIDINEDIONE, INSULIN SECRETAGOGUE AND ALPHA GLUCOCIDASE INHIBITOR | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-01-28 | — | — | WO | claimed |
| WO-1999003476-A1 | TREATMENT OF DIABETES WITH THIAZOLIDINEDIONE AND SULPHONYLUREA | SMITHKLINE BEECHAM PLC (GB) | 1999-01-28 | — | — | WO | claimed |
| WO-1999003477-A1 | TREATMENT OF DIABETES WITH THIAZOLIDINEDIONE, INSULIN SECRETAGOGUE AND DIGUANIDE | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-01-28 | — | — | WO | claimed |
| WO-1998056378-A1 | NOVEL NIDDM REGIMEN | NOVO NORDISK A/S (DK) | 1998-12-17 | — | — | WO | claimed |
| WO-1998022114-A1 | A METHOD FOR PROMOTING TISSUE REPAIR | DUMEX-ALPHARMA A/S (DK) | 1998-05-28 | — | — | WO | claimed |
| US-5631224-A | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 1997-05-20 | — | — | US | claimed |
| US-5349100-A | Chiral metallocene compounds and preparation thereof by creation of a chiral center by enantioselective hydride transfer | EXXON CHEMICAL PATENTS INC. (US) | 1994-09-20 | — | — | US | claimed |
| WO-1992012112-A1 | CHIRAL METALLOCENE COMPOUNDS AND PREPARATION THEREOF BY CREATION OF A CHIRAL CENTER BY ENANTIOSELECTIVE HYDRIDE TRANSFER | EXXON CHEMICAL PATENTS INC. (US) | 1992-07-23 | — | — | WO | claimed |