ABCC8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1289338	0.57	17/20
SCHEMBL1002731	0.73	15/20
SCHEMBL561467	0.62	13/20
SCHEMBL562109	0.62	13/20
SCHEMBL589730	0.56	9/20
SCHEMBL809999	0.48	7/20
SCHEMBL810062	0.48	7/20
SCHEMBL810190	0.48	7/20
SCHEMBL810341	0.48	7/20
SCHEMBL811109	0.48	7/20
SCHEMBL880238	0.41	6/20
SCHEMBL256602	0.48	5/20
SCHEMBL1312972	0.45	5/20
SCHEMBL718487	0.56	4/20
SCHEMBL717798	0.52	4/20
SCHEMBL195265	0.47	4/20
SCHEMBL810074	0.47	4/20
SCHEMBL810083	0.47	4/20
SCHEMBL810207	0.47	4/20
SCHEMBL810219	0.47	4/20

Clinical trials — most relevant to ABCC8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes	PHASE4	COMPLETED
Sulphonylurea Receptor Mutation and Responsiveness to Gliclazide - a Pilot Proof of Concept, Randomised Cross-over Study	PHASE4	COMPLETED
Paclitaxel, Nab-paclitaxel, or Ixabepilone With or Without Bevacizumab in Treating Patients With Stage IIIC or Stage IV Breast Cancer	PHASE3	COMPLETED
Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels	PHASE3	COMPLETED
8-Chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia	PHASE1/PHASE2	COMPLETED
Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer	PHASE2	COMPLETED
A Phase 2 Trial of SCO-101 in Combination With FOLFIRI for Patients With Metastatic Colorectal Cancer (mCRC) With Acquired Resistance to FOLFIRI	PHASE1/PHASE2	UNKNOWN
Clofarabine and Cytarabine in Treating Young Patients With Refractory or Relapsed Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia	PHASE1/PHASE2	COMPLETED
Influence of Ethnicity and ABCB1 Gene Polymorphism on the Pharmacokinetics of Azithromycin in Healthy Bangladeshi Volunteers	PHASE1	UNKNOWN
Veliparib and Irinotecan Hydrochloride in Treating Patients With Cancer That Is Metastatic or Cannot Be Removed by Surgery	PHASE1	COMPLETED
Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas	PHASE1	COMPLETED
Icotinib Hydrochloride in Treating Patients With Advanced Cancers	PHASE1	WITHDRAWN
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia	nan	ACTIVE_NOT_RECRUITING
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
the Effect of ABCC2 Genetic Polymorphism on Neurotoxicity in Gastrointestinal Cancer Patients Receiving Oxaliplatin	nan	UNKNOWN
Genetic Study for Infantile Onset Diabetes Mellitus	nan	UNKNOWN
Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors	nan	WITHDRAWN
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Placental Transfer of Tenofovir	nan	COMPLETED
Metformin Reduce the Relapse Rate on Patients With B-cell Precursor (Ph+ Negative) Acute Lymphoblastic Leukemia	nan	COMPLETED
Collection of Tissue Samples for Study of Multidrug Resistance	nan	COMPLETED
Impact of Genetics on Metformin Pharmacokinetics	nan	COMPLETED
Role of the ATP7A Transporter in Ovarian Cancer	nan	COMPLETED
Studying DNA in Tissue Samples From Caucasian and African-American Cancer Patients Who Received Docetaxel on Clinical Trial CLB-9871	nan	COMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients	nan	UNKNOWN
Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia	nan	UNKNOWN
Pharmacogenomics of Paclitaxel in Ovarian Cancer	nan	COMPLETED
Pharmacogenetics Study in Taiwan's Ethnic Groups	nan	COMPLETED
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ABCC8 binder may also engage these)

Protein	Name	Similarity
Q09429	—	1.000	Q09429 →
Q09427	—	1.000	Q09427 →
Q63563	—	1.000	Q63563 →
P82451	—	1.000	P82451 →
Q9R1X5	—	1.000	Q9R1X5 →
Q9QYM0	—	1.000	Q9QYM0 →
P70170	—	1.000	P70170 →
ABCC9	ATP-binding cassette sub-family C member 9	1.000	landscape →
Q96J66	—	1.000	Q96J66 →
Q9C8G9	—	0.999	Q9C8G9 →
Q63120	—	0.999	Q63120 →
Q9U2G5	—	0.999	Q9U2G5 →
ABCC5	ATP-binding cassette sub-family C member 5	0.998	landscape →
B2RX12	—	0.997	B2RX12 →
Q00554	—	0.997	Q00554 →
P26361	—	0.997	P26361 →
Q00555	—	0.997	Q00555 →
Q2QLB4	—	0.997	Q2QLB4 →
Q8LGU1	—	0.997	Q8LGU1 →
Q00PJ2	—	0.996	Q00PJ2 →
Q9LZJ5	—	0.996	Q9LZJ5 →
Q1LX78	—	0.996	Q1LX78 →
O35379	—	0.996	O35379 →
Q9M1C7	—	0.996	Q9M1C7 →
P35071	—	0.996	P35071 →
Q9TSP5	—	0.996	Q9TSP5 →
Q2QLE5	—	0.996	Q2QLE5 →
Q07DZ6	—	0.995	Q07DZ6 →
Q2QLC5	—	0.995	Q2QLC5 →
A2XCD4	—	0.995	A2XCD4 →