Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 13/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.58 |
| ▸ | F12 | P00748 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373313 | 0.92 | BAZ2B (0.63) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL30228387 | 0.88 | TRPV1 (0.59) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL2832897 | 0.88 | LMNA (0.76) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL409534 | 0.87 | BAZ2B (0.71) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL21114757 | 0.87 | BAZ2B (0.71) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL5104575 | 0.87 | BAZ2B (0.71) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL3312381 | 0.86 | LMNA (0.57) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL21162488 | 0.86 | BAZ2B (0.74) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL30228575 | 0.86 | BAZ2B (0.74) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 | |
| SCHEMBL5107538 | 0.85 | CFTR (0.61) | BAZ2BLMNAPABPC1ATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014155300-A2 | SUBSTITUED PYRIMIDINE AMINE DERIVATIVES AS TAK-1 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-10-02 | — | — | WO | disclosed |