Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 12/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18796762 | 0.98 | PDE3B (0.96) | PDE3BPDE3AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL16140693 | 0.92 | PDE3B (0.86) | PDE3BPDE3AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL16140686 | 0.91 | PDE3B (0.84) | PDE3BPDE3AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL16140694 | 0.90 | PDE3B (0.81) | PDE3BPDE3AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL16140688 | 0.89 | PDE3B (1.00) | PDE3BPDE3AKDM4ELMNAMAPT | |
| SCHEMBL16140691 | 0.89 | PDE3B (1.00) | PDE3BPDE3AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL16140677 | 0.89 | PDE3B (1.00) | PDE3BPDE3AKDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL18796725 | 0.89 | PDE3B (0.80) | PDE3BPDE3AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL16140680 | 0.89 | PDE3B (0.80) | PDE3BPDE3AKDM4ESMN1; SMN2LMNA | |
| SCHEMBL18796702 | 0.88 | PDE3B (0.94) | PDE3BPDE3AKDM4ETP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562045-B2 | Process for preparation of indolizine based derivatives as potential phosphodiestrase 3 (PDE3) inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-02-07 | — | — | US | disclosed |
| US-9562045-B2 | Process for preparation of indolizine based derivatives as potential phosphodiestrase 3 (PDE3) inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-02-07 | — | — | US | disclosed |
| US-9562045-B2 | Process for preparation of indolizine based derivatives as potential phosphodiestrase 3 (PDE3) inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-02-07 | — | — | US | disclosed |
| US-20160159792-A1 | PROCESS FOR PREPARATION OF INDOLIZINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTRASE 3 (PDE3) INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-06-09 | — | — | US | disclosed |
| US-20160159792-A1 | PROCESS FOR PREPARATION OF INDOLIZINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTRASE 3 (PDE3) INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-06-09 | — | — | US | disclosed |
| US-20160159792-A1 | PROCESS FOR PREPARATION OF INDOLIZINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTRASE 3 (PDE3) INHIBITORS | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-06-09 | — | — | US | disclosed |
| US-9249139-B2 | Indolizinone based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-02-02 | — | — | US | disclosed |
| US-9249139-B2 | Indolizinone based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2016-02-02 | — | — | US | disclosed |
| US-20140296530-A1 | INDOLIZINONE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-10-02 | — | — | US | disclosed |
| US-20140296530-A1 | INDOLIZINONE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296530-A1 | INDOLIZINONE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | PDE3A, PDE3B, PDE5A | PDE3B 2/4885PDE3A 1/4885KDM4E 2478/4885 |
| US-20160159792-A1 | PROCESS FOR PREPARATION OF INDOLIZINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTRASE 3 (PDE3) INHIBITORS | PDE3A, PDE5A, PDE3B | PDE3B 3/4885PDE3A 1/4885KDM4E 2250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.