Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.94 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.94 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16140677 | 0.97 | PDE3B (1.00) | PDE3BPDE3AGAAALDH1A1GABRA1 | |
| SCHEMBL16140693 | 0.91 | PDE3B (0.86) | PDE3BPDE3AGAAALDH1A1ALOX15 | |
| SCHEMBL18796767 | 0.90 | PDE3B (0.96) | PDE3BPDE3AGAAALDH1A1ALOX15 | |
| SCHEMBL18796662 | 0.90 | PDE3B (0.96) | PDE3BPDE3AGAAALDH1A1ALOX15 | |
| SCHEMBL18796762 | 0.90 | PDE3B (0.96) | PDE3BPDE3AGAAALDH1A1ALOX15 | |
| SCHEMBL16140686 | 0.90 | PDE3B (0.84) | PDE3BPDE3AGAAALDH1A1ALOX15 | |
| SCHEMBL18796705 | 0.89 | PDE3B (0.74) | PDE3BPDE3AGAAALDH1A1TP53 | |
| SCHEMBL18796678 | 0.89 | PDE3B (0.78) | PDE3BPDE3AGAAALDH1A1ALOX15 | |
| SCHEMBL18796739 | 0.89 | PDE3B (0.94) | PDE3BPDE3AGAAALDH1A1ALOX15 | |
| SCHEMBL18796778 | 0.89 | PDE3B (0.94) | PDE3BPDE3AGAAALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | claimed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017072796-A1 | 2-PYRIDONE BASED COMPOUNDS USEFUL AS POTENTIAL PHOSPHODIESTERASE3A (PDE3A)INHIBITORS AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2017-05-04 | — | — | WO | disclosed |