Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | PLAT | P00750 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279133 | 0.87 | PDGFRB (0.45) | PDGFRBPARP1LMNASMN1; SMN2PTGES | |
| SCHEMBL1613592 | 0.86 | KDM4E (0.43) | PARP1PLATLMNASMN1; SMN2KMT2A | |
| SCHEMBL1614570 | 0.86 | ADORA2A (0.40) | LMNASMN1; SMN2KMT2AKDM4EHSD17B10 | |
| SCHEMBL1614781 | 0.85 | PARP1 (0.44) | PDGFRBPARP1PLATLMNASMN1; SMN2 | |
| SCHEMBL1614156 | 0.82 | KMT2A (0.39) | PARP1SMN1; SMN2KMT2AKDM4EHSD17B10 | |
| SCHEMBL1614119 | 0.79 | DHFR (0.40) | PLATSMN1; SMN2KDM4E | |
| SCHEMBL19084584 | 0.79 | PSD (0.54) | PARP1LMNASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL1613743 | 0.78 | SMN1; SMN2 (0.47) | PARP1PLATLMNASMN1; SMN2KMT2A | |
| SCHEMBL1614608 | 0.78 | PSD (0.47) | SMN1; SMN2KMT2APOLBMAPT | |
| SCHEMBL1614238 | 0.78 | KCNQ3 (0.38) | PLATKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |
| US-20120088775-A1 | Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof | PEKING UNIVERSITY (CN) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088775-A1 | Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof | KCNJ2, KCNQ5, KCNJ11 | PDGFRB 1475/4885PARP1 640/4885PLAT 1286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.