Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.53 |
| ▸ | CTSV | O60911 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NSD2 | O96028 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108329 | 1.00 | NT5E (0.61) | NT5EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL141078 | 0.99 | NT5E (0.60) | NT5EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL141080 | 0.99 | NT5E (0.60) | NT5EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL141081 | 0.99 | NT5E (0.60) | NT5EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL7820869 | 0.89 | NT5E (0.67) | NT5EMAPTMEN1KMT2AGFER | |
| SCHEMBL112129 | 0.88 | TDP1 (0.62) | NT5EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL456694 | 0.88 | TDP1 (0.62) | NT5EMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL141079 | 0.88 | MAPT (0.57) | MAPTMEN1KMT2AMAPK1GFER | |
| SCHEMBL29357322 | 0.88 | MAPT (0.57) | MAPTMEN1KMT2AMAPK1GFER | |
| SCHEMBL13588699 | 0.87 | TDP1 (0.54) | NT5EMAPTMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200289667-A1 | Targeting Macrophages to Modulate Electrical Conduction in the Heart | THE GENERAL HOSPITAL CORPORATION | 2020-09-17 | — | — | US | claimed |
| US-20190054184-A1 | Targeting Macrophages to Modulate Electrical Conduction in the Heart | THE GENERAL HOSPITAL CORPORATION | 2019-02-21 | — | — | US | claimed |
| WO-2017139757-A1 | TARGETING MACROPHAGES TO MODULATE ELECTRICAL CONDUCTION IN THE HEART | THE GENERAL HOSPITAL CORPORATION (US) | 2017-08-17 | — | — | WO | claimed |
| CN-112368441-B | Functionalized fibrous material | HBI品牌服饰企业有限公司 | 2022-12-30 | — | — | CN | disclosed |
| US-20200289667-A1 | Targeting Macrophages to Modulate Electrical Conduction in the Heart | THE GENERAL HOSPITAL CORPORATION | 2020-09-17 | — | — | US | disclosed |
| US-20190054184-A1 | Targeting Macrophages to Modulate Electrical Conduction in the Heart | THE GENERAL HOSPITAL CORPORATION | 2019-02-21 | — | — | US | disclosed |
| US-10064842-B2 | KCNQ channels as therapeutic targets | WASHINGTON UNIVERSITY (US) | 2018-09-04 | — | — | US | disclosed |
| WO-2017139757-A1 | TARGETING MACROPHAGES TO MODULATE ELECTRICAL CONDUCTION IN THE HEART | THE GENERAL HOSPITAL CORPORATION (US) | 2017-08-17 | — | — | WO | disclosed |
| US-20160228411-A1 | KCNQ CHANNELS AS THERAPEUTIC TARGETS | WASHINGTON UNIVERSITY (US) | 2016-08-11 | — | — | US | disclosed |
| US-9345688-B2 | KCNQ channels as therapeutic targets | WASHINGTON UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140303226-A1 | KCNQ CHANNELS AS THERAPEUTIC TARGETS | WASHINGTON UNIVERSITY (US) | 2014-10-09 | — | — | US | disclosed |