Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 known ✓ | Q9H244 | 2/20 | 0.51 |
| ▸ | P2RY2 known ✓ | P41231 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.50 |
| ▸ | CTSV | O60911 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29357322 | 1.00 | MAPT (0.57) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL141080 | 0.89 | NT5E (0.60) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL29465202 | 0.88 | MAPT (0.62) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL108329 | 0.88 | NT5E (0.61) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL16147671 | 0.88 | NT5E (0.61) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL141081 | 0.87 | NT5E (0.60) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL141078 | 0.87 | NT5E (0.60) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL3272499 | 0.85 | MAPT (0.73) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL293916 | 0.84 | MAPT (0.72) | MAPTMEN1KMT2AMAPK1TDP1 | |
| SCHEMBL10720749 | 0.84 | MAPT (0.63) | MAPTMEN1KMT2AMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 123 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2930126-B1 | Fashionable aerosol dye | HENKEL AG & CO KGAA (DE) | 2019-10-09 | — | — | EP | claimed |
| US-10259946-B1 | Sealing agents, methods of making and uses thereof | James Hardie Technology Limited (IE) | 2019-04-16 | — | — | US | disclosed |
| US-9693937-B2 | Foil applicator | HENKEL AG & CO. KGAA (DE) | 2017-07-04 | — | — | US | disclosed |
| US-9173829-B2 | Compositions for dyeing keratin fibers | HENKEL AG & CO. KGAA (DE) | 2015-11-03 | — | — | US | disclosed |
| US-9161898-B2 | Compositions for colouring keratin fibres | HENKEL AG & CO. KGAA (DE) | 2015-10-20 | — | — | US | disclosed |
| US-20150174019-A1 | FOIL APPLICATOR | HENKEL AG & CO. KGAA (DE) | 2015-06-25 | — | — | US | disclosed |
| EP-2852440-A1 | SOLUBLE SOLID HAIR COLORING ARTICLE | The Procter & Gamble Company (US) | 2015-04-01 | — | — | EP | disclosed |
| US-20140298592-A1 | COMPOSITIONS FOR DYEING KERATIN FIBERS | HENKEL AG & CO. KGAA (DE) | 2014-10-09 | — | — | US | disclosed |
| US-20140290690-A1 | COMPOSITIONS FOR COLOURING KERATIN FIBRES | HENKEL AG & CO. KGAA (DE) | 2014-10-02 | — | — | US | disclosed |
| US-8632612-B2 | Compositions for dyeing keratin fibers | SEGETIS, INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-6558433-B2 | Oxidation hair dye | WELLA AG (DE) | 2003-05-06 | — | — | US | disclosed |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | Wella GmbH (DE) | 2003-03-06 | — | — | US | disclosed |
| US-20020189031-A1 | Use of salts for improving the absorption qualities of anionic direct dyes | WELLA AKTIENGESELLSCHAFT (DE) | 2002-12-19 | — | — | US | disclosed |
| US-6485529-B1 | Agent and method for coloring fibers | WELLA AKTIENGESELLSCHAFT (DE) | 2002-11-26 | — | — | US | disclosed |
| US-20020170125-A1 | Bridged diaminopyrazole compounds and dye compositions containing same | HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) | 2002-11-21 | — | — | US | disclosed |
| US-6461390-B1 | Process for making 2-aminomethyl-1, 4-diaminobenzene and its salts and compositions and methods for dyeing keratin fibers using same | WELLA AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |
| US-6379400-B1 | DYEING FIBERS, SOLVENT OF WATER OR ALCOHOL AND NITROANILINE DYE | WELLA AKTIENGESELLSCHAFT (DE) | 2002-04-30 | — | — | US | disclosed |
| US-6361571-B1 | USING TAUTOMERIC NONOXIDATIVE DYES AND POLYMETHINE DYES | WELLA AKTIENGESELLSCHAFT (DE) | 2002-03-26 | — | — | US | disclosed |
| US-6171347-B1 | REMOVAL OF HAIR COLOR TO BE WORN FOR ONLY A SHORT PERIOD OF TIME UNDER MILD, GENTLE CONDITIONS BY USING A COMBINATION OF A SUITABLE REDUCTONE, SUCH AS ASCORBIC ACID, AND/OR A THIOL AND/OR A SULFITE | WELLA AKTIENGESELLSCHAFT (DE) | 2001-01-09 | — | — | US | disclosed |
| US-6106579-A | MIXTURE OF OXOCARBOXYLIC ACID AND REDUCING AGENT | WELLA AKTIENGESELLSCHAFT (DE) | 2000-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140290690-A1 | COMPOSITIONS FOR COLOURING KERATIN FIBRES | KRT18, DSG1, PKN1 | P2RY12 4341/4885P2RY2 4746/4885MAPT 546/4885 |
| US-20140298592-A1 | COMPOSITIONS FOR DYEING KERATIN FIBERS | KRT18, PKN3, IK | P2RY12 4851/4885P2RY2 4839/4885MAPT 2581/4885 |
| US-20030041392-A1 | Process for making 1,4-diamino-2-methoxymethylbenzene and salts thereof and compositions and methods for dyeing keratin fibers containing same | KRT18, SCNN1B, DDAH1 | P2RY12 3799/4885P2RY2 3457/4885MAPT 2639/4885 |
| US-20020170125-A1 | Bridged diaminopyrazole compounds and dye compositions containing same | ALK, DDC, CBR1 | P2RY12 4002/4885P2RY2 2091/4885MAPT 4236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.