Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 13/20 | 0.63 |
| ▸ | P2RX1 | P51575 | 9/20 | 0.63 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.63 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MYLK | Q15746 | 1/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17498479 | 0.89 | TMPRSS4 (0.61) | TMPRSS4P2RX1P2RX4P2RX7TRPV1 | |
| SCHEMBL28199416 | 0.80 | P2RX1 (0.68) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL16147304 | 0.79 | PLAU (0.70) | TMPRSS4P2RX1MEN1KMT2ATYK2 | |
| SCHEMBL130439 | 0.78 | P2RX1 (0.81) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL3497954 | 0.78 | TMPRSS4 (0.64) | TMPRSS4P2RX1P2RX4P2RX7TRPV1 | |
| SCHEMBL29617517 | 0.78 | TMPRSS4 (1.00) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL331631 | 0.78 | TMPRSS4 (1.00) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL16148438 | 0.77 | PLG (0.65) | TMPRSS4P2RX1P2RX4P2RX7TRPV1 | |
| SCHEMBL7511475 | 0.77 | TMPRSS4 (0.62) | TMPRSS4P2RX1P2RX4P2RX7TRPV1 | |
| SCHEMBL24824532 | 0.76 | P2RX1 (0.79) | TMPRSS4P2RX1P2RX4P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014165816-A1 | COMPOUNDS USEFUL FOR THE TREATMENT OF METABOLIC DISORDERS AND SYNTHESIS OF THE SAME | NORTH CAROLINA CENTRAL UNIVERSITY (US) | 2014-10-09 | — | — | WO | disclosed |