Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 5/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.38 |
| ▸ | PLAT | P00750 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1614238 | 0.90 | KCNQ3 (0.38) | KCNQ3KCNQ2PLATHTR2AHTR2C | |
| SCHEMBL1613890 | 0.88 | KCNQ3 (0.49) | KCNQ3KCNQ2PLATHTR2AHTR2C | |
| SCHEMBL1279220 | 0.86 | KCNQ3 (0.43) | KCNQ3KCNQ2LDHAPSD | |
| SCHEMBL1613456 | 0.84 | KCNQ3 (0.42) | KCNQ3KCNQ2PLAT | |
| SCHEMBL1614570 | 0.83 | ADORA2A (0.40) | KCNQ3KCNQ2HTR2AHTR2CADORA2A | |
| SCHEMBL1614119 | 0.81 | DHFR (0.40) | KCNQ3KCNQ2PLATHTR2AHTR2C | |
| SCHEMBL1614156 | 0.80 | KMT2A (0.39) | HTR2AHTR2CPSD | |
| SCHEMBL1614738 | 0.79 | KCNQ3 (0.46) | KCNQ3KCNQ2PLAT | |
| SCHEMBL1614110 | 0.78 | KCNQ3 (0.45) | KCNQ3KCNQ2PLATHTR2AHTR2C | |
| SCHEMBL1613592 | 0.78 | KDM4E (0.43) | PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |
| US-20120088775-A1 | Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof | PEKING UNIVERSITY (CN) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088775-A1 | Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof | KCNJ2, KCNQ5, KCNJ11 | KCNQ3 12/4885KCNQ2 9/4885PLAT 1286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.