Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | OXER1 | Q8TDS5 | 9/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15231785 | 0.83 | NR1H2 (0.51) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4592266 | 0.78 | IDH1 (0.43) | OXER1MCL1MEN1KMT2A | |
| SCHEMBL16835425 | 0.76 | OXER1 (0.46) | CYP1A2OXER1MCL1L3MBTL1KMT2A | |
| SCHEMBL7551690 | 0.75 | OXER1 (0.59) | OXER1NOD2NOD1MCL1 | |
| SCHEMBL7459847 | 0.74 | OXER1 (0.48) | OXER1MCL1L3MBTL1KMT2A | |
| SCHEMBL1465160 | 0.72 | NOD2 (0.47) | OXER1NOD2NOD1L3MBTL1MEN1 | |
| SCHEMBL16150322 | 0.72 | CYP1A2 (0.39) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4760174 | 0.71 | NR1H2 (0.45) | OXER1MCL1L3MBTL1 | |
| SCHEMBL25256217 | 0.70 | MCL1 (0.39) | CYP1A2CYP3A4CYP2D6OXER1NOD2 | |
| SCHEMBL17422801 | 0.69 | DAO (0.46) | OXER1MCL1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970099-A1 | SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014164905-A1 | SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2014-10-09 | — | — | WO | disclosed |