Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16151518 | 0.93 | TMPRSS2 (0.31) | TMPRSS2 | |
| SCHEMBL12393223 | 0.92 | CA12 (0.37) | TMPRSS2CA12CA1CA2CA9 | |
| SCHEMBL12393406 | 0.85 | CA12 (0.36) | TMPRSS2CA12CA1CA2CA9 | |
| SCHEMBL21283649 | 0.84 | TMPRSS2 (0.41) | TMPRSS2 | |
| SCHEMBL10142507 | 0.82 | POLRMT (0.38) | TMPRSS2 | |
| SCHEMBL24119311 | 0.80 | TMPRSS2 (0.43) | TMPRSS2CA12CA1CA2CA9 | |
| SCHEMBL10120864 | 0.80 | TMPRSS2 (0.43) | TMPRSS2CA12CA1CA2CA9 | |
| SCHEMBL22096273 | 0.78 | CA12 (0.36) | TMPRSS2CA12CA1CA2CA9 | |
| SCHEMBL10142499 | 0.78 | POLRMT (0.47) | — | |
| SCHEMBL22646485 | 0.78 | TMPRSS2 (0.42) | TMPRSS2CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46762-E1 | 1′-substituted carba-nucleoside analogs for antiviral treatment | GILEAD SCIENCES, INC (US) | 2018-03-27 | — | — | US | disclosed |
| US-8853171-B2 | 1′-substituted carba-nucleoside analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2014-10-07 | — | — | US | disclosed |