SCHEMBL16153103

SCHEMBL16153103

CCc1nc2cc(-n3c(S)nnc3-c3cc(CC)c(O)cc3O)ccc2o1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.41
P2RX3 P56373 1/20 0.36
HSP90AA1 P07900 4/20 0.32
HSP90AB1 P08238 4/20 0.32
TAS2R8 Q9NYW2 1/20 0.32
MAPT P10636 4/20 0.32
KDM4E B2RXH2 3/20 0.32
LMNA P02545 1/20 0.32
PAX8 Q06710 1/20 0.32
RAB9A P51151 3/20 0.31
NPC1 O15118 2/20 0.31
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
ALDH1A1 P00352 2/20 0.31
TP53 P04637 2/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
TDP1 Q9NUW8 2/20 0.31
ALOX15 P16050 1/20 0.31
HTT P42858 1/20 0.31
TAS1R3 Q7RTX0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8931262 0.91 RAB9A (0.34) GAAHSP90AA1HSP90AB1MAPTKDM4E
SCHEMBL930725 0.81 PHGDH (0.34) GAAHSP90AA1HSP90AB1MAPTKDM4E
SCHEMBL419127 0.80 KMT2A (0.44) GAAMAPTKDM4ELMNARAB9A
SCHEMBL13983495 0.79 HSP90AA1 (0.33) GAAHSP90AA1HSP90AB1MAPTKDM4E
SCHEMBL16772875 0.79 HSP90AA1 (0.37) GAAHSP90AA1HSP90AB1MAPTKDM4E
SCHEMBL3701216 0.78 MAPT (0.35) GAAHSP90AA1HSP90AB1MAPTKDM4E
SCHEMBL419819 0.78 KMT2A (0.36) GAAHSP90AA1HSP90AB1MAPTKDM4E
SCHEMBL1148450 0.77 HSP90AA1 (0.32) GAAHSP90AA1HSP90AB1MAPTKDM4E
SCHEMBL419879 0.77 HSP90AA1 (0.53) HSP90AA1HSP90AB1
SCHEMBL420140 0.77 HSP90AA1 (0.38) GAAHSP90AA1HSP90AB1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2490688-B1 COMBINATION CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS SYNTA PHARMACEUTICALS CORP (US) 2014-10-08 EP disclosed