SCHEMBL16155960

SCHEMBL16155960

COCNC(=O)c1c(C)nc2c(N3CCOCC3)nccn12

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 1/20 0.49
PDE10A Q9Y233 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6937842 0.81 PDE10A (0.49) PDE10A
SCHEMBL6937081 0.81 SMN1; SMN2 (0.51)
SCHEMBL6937998 0.80 PDE10A (0.48) PDE10A
SCHEMBL6934951 0.79
SCHEMBL14329229 0.75
SCHEMBL16920992 0.73 PDE10A (0.55) PDE10A
SCHEMBL2447847 0.71 PDE10A (0.57) PDE10A
SCHEMBL6934688 0.71 PDE10A (0.53) PDE10A
SCHEMBL2485195 0.71
SCHEMBL2481832 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8859543-B2 Imidazo[1,2-a]pyrazine derivatives and their use for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases JANSSEN PHARMACEUTICA NV (BE) 2014-10-14 US disclosed