Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.59 |
| ▸ | LCK | P06239 | 9/20 | 0.59 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | RET | P07949 | 4/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | GAK | O14976 | 2/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.53 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.53 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16150108 | 0.82 | EGFR (0.69) | EGFRLCKKDRRETGAK | |
| Hydrochloric Acid SCHEMBL16150696 | 0.81 | EGFR (0.69) | EGFRLCKKDRRETGAK | |
| SCHEMBL16150570 | 0.79 | EGFR (0.52) | EGFRLCKKDRCLK1ABCG2 | |
| SCHEMBL19035526 | 0.78 | EGFR (0.62) | EGFRLCKKDRRETSRC | |
| SCHEMBL5652748 | 0.74 | KDR (0.72) | EGFRLCKKDRRETSRC | |
| SCHEMBL2659830 | 0.74 | KDR (0.61) | EGFRLCKKDRRETGAK | |
| SCHEMBL7705790 | 0.74 | EGFR (1.00) | EGFRLCKKDRRETSRC | |
| Hydrochloric Acid SCHEMBL6180756 | 0.74 | EGFR (1.00) | EGFRLCKKDRRETGAK | |
| SCHEMBL8976587 | 0.72 | EGFR (0.70) | EGFRLCKKDRRETSRC | |
| SCHEMBL5478005 | 0.72 | EGFR (1.00) | EGFRLCKKDRRETGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688662-B2 | N-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-quinazolinamine and N-(2,3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives as perk inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-27 | — | — | US | disclosed |
| EP-2989091-B1 | NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-4- QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4- QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-10 | — | — | EP | disclosed |
| WO-2014161808-A1 | NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]JPYRIDIN-5-YL)-4- QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4- QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-09 | — | — | WO | disclosed |