Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.72 |
| ▸ | RET | P07949 | 5/20 | 0.72 |
| ▸ | EGFR | P00533 | 16/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.71 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.71 |
| ▸ | LCK | P06239 | 6/20 | 0.69 |
| ▸ | SRC | P12931 | 2/20 | 0.68 |
| ▸ | GAK | O14976 | 2/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.65 |
| ▸ | KIF5B | P33176 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 1/20 | 0.64 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.64 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.64 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.64 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5649924 | 0.88 | EGFR (0.67) | KDRRETEGFRCLK1ABCG2 | |
| SCHEMBL3533221 | 0.84 | EGFR (0.80) | KDRRETEGFRCLK1ABCG2 | |
| SCHEMBL5569018 | 0.84 | KDR (1.00) | KDRRETEGFRCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL8871198 | 0.83 | EGFR (0.80) | KDRRETEGFRCLK1ABCG2 | |
| SCHEMBL5565137 | 0.83 | EGFR (1.00) | KDRRETEGFRCLK1ABCG2 | |
| Hydrochloric Acid SCHEMBL1507643 | 0.83 | KDR (0.97) | KDRRETEGFRCLK1ABCG2 | |
| SCHEMBL6783334 | 0.82 | KDR (0.74) | KDRRETEGFRCLK1ABCG2 | |
| SCHEMBL5474772 | 0.81 | KDR (1.00) | KDRRETEGFRABCG2LCK | |
| SCHEMBL6787016 | 0.81 | KDR (0.74) | KDRRETEGFRCLK1ABCG2 | |
| SCHEMBL20812874 | 0.81 | EGFR (0.80) | KDRRETEGFRCLK1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |