Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16158486 | 0.89 | FGFR1 (0.59) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL2642019 | 0.88 | FGFR1 (0.60) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL16147532 | 0.85 | FGFR1 (0.68) | FGFR1HTTMAPTKMT2APTK2B | |
| SCHEMBL16147183 | 0.82 | FGFR1 (0.74) | FGFR1HTTALDH1A1KDR | |
| SCHEMBL22329065 | 0.82 | FGFR1 (0.53) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL4015486 | 0.82 | HTT (0.71) | FGFR1HTTMAPTKMT2APTK2B | |
| SCHEMBL2306019 | 0.82 | FGFR1 (0.67) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL16148290 | 0.81 | FGFR1 (0.64) | FGFR1HTTALDH1A1KDR | |
| SCHEMBL16147687 | 0.81 | FGFR1 (0.51) | FGFR1HTTKDM4EALDH1A1RAB9A | |
| SCHEMBL2643550 | 0.81 | FGFR1 (0.78) | FGFR1HTTALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014165815-A2 | NONSTEROIDAL AND STEROIDAL COMPOUNDS WITH POTENT ANDROGEN RECEPTOR DOWN-REGULATION AND ANTI PROSTATE CANCER ACTIVITY | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2014-10-09 | — | — | WO | disclosed |