Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16149331 | 1.00 | PARP1 (0.75) | PARP1LMNAMAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL13946848 | 0.86 | PARP1 (0.67) | PARP1LMNAMAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL3569611 | 0.86 | PLK4 (0.74) | PARP1LMNAGSK3BPSDPARP2 | |
| SCHEMBL3569608 | 0.86 | PLK4 (0.74) | PARP1LMNAGSK3BPSDPARP2 | |
| SCHEMBL13343866 | 0.86 | PLK4 (0.74) | PARP1LMNAGSK3BPSDPARP2 | |
| SCHEMBL12233307 | 0.86 | PARP1 (0.67) | PARP1LMNAMAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL1301398 | 0.83 | PDGFRB (0.76) | LMNAMAPK1SMN1; SMN2LRRK2PDGFRB | |
| SCHEMBL247890 | 0.83 | PDGFRB (0.76) | LMNAMAPK1SMN1; SMN2LRRK2PDGFRB | |
| SCHEMBL29875506 | 0.83 | PDGFRB (0.76) | LMNAMAPK1SMN1; SMN2LRRK2PDGFRB | |
| SCHEMBL247891 | 0.83 | PDGFRB (0.76) | LMNAMAPK1SMN1; SMN2LRRK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014164667-A1 | DENGUE AND WEST NILE VIRUS PROTEASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2014-10-09 | — | — | WO | disclosed |