Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 4/20 | 0.76 |
| ▸ | PLK4 | O00444 | 2/20 | 0.76 |
| ▸ | PLK1 | P53350 | 2/20 | 0.76 |
| ▸ | RET | P07949 | 1/20 | 0.76 |
| ▸ | FLT3 | P36888 | 1/20 | 0.76 |
| ▸ | KDR | P35968 | 1/20 | 0.76 |
| ▸ | PIM1 | P11309 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | APP | P05067 | 5/20 | 0.69 |
| ▸ | SNCA | P37840 | 5/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | CTRC | Q99895 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | GMNN | O75496 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29875506 | 1.00 | PDGFRB (0.76) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL247891 | 1.00 | PDGFRB (0.76) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL1301398 | 1.00 | PDGFRB (0.76) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL16442340 | 0.90 | PDGFRB (0.72) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL16442341 | 0.86 | PDGFRB (1.00) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL5475546 | 0.86 | KDR (1.00) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL5319070 | 0.86 | MAPT (0.71) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL5470603 | 0.86 | PDGFRB (1.00) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL5481962 | 0.86 | PDGFRB (0.72) | PDGFRBPLK4PLK1RETFLT3 | |
| SCHEMBL3284695 | 0.86 | FLT3 (0.66) | PDGFRBPLK4PLK1RETFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057755-B | Preparation method and application of iridoid aglycone-based spiro indolone compound | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-08-30 | — | — | CN | disclosed |
| CN-114057755-A | Preparation method and application of iridoid aglycone-based spiro indolone compound | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-02-18 | — | — | CN | disclosed |
| US-9302120-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-04-05 | — | — | US | disclosed |
| US-9302120-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-04-05 | — | — | US | disclosed |
| EP-1856123-B1 | SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF | UNIV MICHIGAN (US) | 2016-02-17 | — | — | EP | disclosed |
| CN-102627649-B | Small molecule inhibitors of MDM2 and uses thereof | UNIV MICHIGAN | 2015-03-25 | — | — | CN | disclosed |
| US-8980926-B2 | 2-aminoindole compounds and methods for the treatment of malaria | GENZYME CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-8980926-B2 | 2-aminoindole compounds and methods for the treatment of malaria | GENZYME CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-8901117-B2 | Small molecule inhibitors of MDM2 and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-12-02 | — | — | US | disclosed |
| US-8742121-B2 | Process for the preparation of small molecule inhibitors of MDM2 and intermediates used therein | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-06-03 | — | — | US | disclosed |
| US-8088931-B2 | Small molecule inhibitors of MDM2 and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-01-03 | — | — | US | disclosed |
| US-7960548-B2 | Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2011-06-14 | — | — | US | disclosed |
| US-7826979-B2 | Method of modeling complex formation between a query ligan and a target molecule | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-02 | — | — | US | disclosed |
| US-7826979-B2 | Method of modeling complex formation between a query ligan and a target molecule | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-02 | — | — | US | disclosed |
| US-20100273799-A1 | SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-10-28 | — | — | US | disclosed |
| US-7759383-B2 | INHIBITORS OF MURINE DOUBLE MINUTE-2(MDM2) SUCH AS (2'R,3'S,4'R,5'R)6-CHLORO-4'-2,2-DIMETHYL-PROPYL-2'-(2,2-DIMETHYL-PROPYL)-2-OXO-1,2-DIHYDRO-SPIRO[INDOLE-3,3'-PYRROLIDINE]-5'-CARBOXYLIC ACID(3-MORPHOLIN-4-YL-PROPYL)-AMIDE, USED FOR INDUCING APOPTOSIS AND CELL CYCLE ARREST; ANTIPROLIFERATIVE AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-07-20 | — | — | US | disclosed |
| EP-1856123-A2 | SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-11-21 | — | — | EP | disclosed |
| US-20070078176-A1 | Keratinocyte growth factor receptor-tyrosine specific inhibitors for the prevention of cancer metastatis | US ARMY, SECRETARY OF THE ARMY | 2007-04-05 | — | — | US | disclosed |
| US-20060211757-A1 | INHIBITORS OF MURINE DOUBLE MINUTE-2(MDM2) SUCH AS (2'R,3'S,4'R,5'R)6-CHLORO-4'-2,2-DIMETHYL-PROPYL-2'-(2,2-DIMETHYL-PROPYL)-2-OXO-1,2-DIHYDRO-SPIRO[INDOLE-3,3'-PYRROLIDINE]-5'-CARBOXYLIC ACID(3-MORPHOLIN-4-YL-PROPYL)-AMIDE, USED FOR INDUCING APOPTOSIS AND CELL CYCLE ARREST; ANTIPROLIFERATIVE AGENTS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-09-21 | — | — | US | disclosed |
| WO-2006091646-A2 | SMALL MOLECULE INHIBITORS OF MDM2 AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078176-A1 | Keratinocyte growth factor receptor-tyrosine specific inhibitors for the prevention of cancer metastatis | FGFR1, FGFR3, MET | PDGFRB 167/4885PLK4 2519/4885PLK1 78/4885 |
| US-20100273799-A1 | SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | TP53, MDM2, CDKN1A | PDGFRB 3053/4885PLK4 496/4885PLK1 61/4885 |
| US-20060211757-A1 | INHIBITORS OF MURINE DOUBLE MINUTE-2(MDM2) SUCH AS (2'R,3'S,4'R,5'R)6-CHLORO-4'-2,2-DIMETHYL-PROPYL-2'-(2,2-DIMETHYL-PROPYL)-2-OXO-1,2-DIHYDRO-SPIRO[INDOLE-3,3'-PYRROLIDINE]-5'-CARBOXYLIC ACID(3-MORPHOLIN-4-YL-PROPYL)-AMIDE, USED FOR INDUCING APOPTOSIS AND CELL CYCLE ARREST; ANTIPROLIFERATIVE AGENTS | SKP2, MDM2, CCAR2 | PDGFRB 1819/4885PLK4 340/4885PLK1 227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.