Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 9/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161618 | 0.83 | MPL (0.42) | KMO | |
| SCHEMBL16971585 | 0.80 | KMO (0.43) | KMOTGFBR1ACVR1BACVRL1ACVR1 | |
| SCHEMBL16161487 | 0.80 | KMO (0.65) | KMO | |
| SCHEMBL16161617 | 0.79 | KMO (0.63) | KMO | |
| SCHEMBL16161655 | 0.78 | KMO (0.66) | KMO | |
| SCHEMBL1938162 | 0.78 | KMO (0.81) | KMOPTGER1 | |
| SCHEMBL16161491 | 0.77 | KMO (0.62) | KMO | |
| SCHEMBL16161393 | 0.76 | KMO (0.63) | KMO | |
| SCHEMBL16161504 | 0.75 | KMO (0.59) | KMO | |
| SCHEMBL16971796 | 0.74 | KMO (0.50) | KMOTGFBR1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331095-B1 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI FOUNDATION INC (US) | 2014-10-15 | — | — | EP | claimed |