Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | CCR9 | P51686 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16162153 | 0.93 | BRAF (0.44) | BRAFMAP3K20 | |
| SCHEMBL16162093 | 0.89 | BRAF (0.45) | BRAFMAP3K20 | |
| SCHEMBL16162114 | 0.87 | BRAF (0.47) | BRAFMAP3K20 | |
| SCHEMBL16162081 | 0.87 | CCR9 (0.39) | BRAFHSD17B2CCR9 | |
| SCHEMBL16162147 | 0.87 | BRAF (0.41) | BRAFMAP3K20 | |
| SCHEMBL16162154 | 0.86 | MAP3K20 (0.43) | BRAFMAP3K20 | |
| SCHEMBL298312 | 0.86 | BRAF (0.47) | BRAFMAP3K20HSD17B2CCR9 | |
| SCHEMBL16162115 | 0.85 | MAP3K20 (0.50) | BRAFMAP3K20 | |
| SCHEMBL16162126 | 0.85 | BRAF (0.44) | BRAFMAP3K20 | |
| SCHEMBL16162118 | 0.85 | CYP2C9 (0.46) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |