Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16162087 | 0.92 | MAP3K20 (0.47) | BRAFMAP3K20PIK3CDPIK3R1PIK3CA | |
| SCHEMBL16162093 | 0.89 | BRAF (0.45) | BRAFMAP3K20PIK3CDPIK3R1PIK3CA | |
| SCHEMBL16162153 | 0.88 | BRAF (0.44) | BRAFMAP3K20 | |
| SCHEMBL299384 | 0.88 | BRAF (0.44) | BRAFMAP3K20KIT | |
| SCHEMBL16161968 | 0.87 | BRAF (0.43) | BRAFMAP3K20 | |
| SCHEMBL16162040 | 0.87 | KIT (0.40) | BRAFKITPIK3CA | |
| SCHEMBL16162114 | 0.85 | BRAF (0.47) | BRAFMAP3K20 | |
| SCHEMBL16162115 | 0.85 | MAP3K20 (0.50) | BRAFMAP3K20PIK3CDPIK3R1PIK3CA | |
| SCHEMBL16162154 | 0.85 | MAP3K20 (0.43) | BRAFMAP3K20 | |
| SCHEMBL16162149 | 0.84 | MAP3K20 (0.44) | BRAFMAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |