Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MAP3K20 | Q9NYL2 | 5/20 | 0.38 |
| ▸ | BRAF | P15056 | 9/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16162040 | 0.92 | KIT (0.40) | BRAFCYP2C9 | |
| SCHEMBL16162106 | 0.90 | CYP3A4 (0.47) | CYP3A4MAP3K20BRAFCYP2C9 | |
| SCHEMBL287808 | 0.88 | BRAF (0.39) | FBP1CYP3A4MAP3K20BRAFCYP2C9 | |
| SCHEMBL16162087 | 0.87 | MAP3K20 (0.47) | FBP1CYP3A4MAP3K20BRAF | |
| SCHEMBL16162113 | 0.86 | BRAF (0.48) | CYP3A4BRAFCYP2C9 | |
| SCHEMBL16162151 | 0.86 | CYP2D6 (0.43) | CYP3A4BRAFCYP2C9 | |
| SCHEMBL16162085 | 0.84 | CYP2C19 (0.44) | CYP3A4MAP3K20BRAFCYP2C9 | |
| SCHEMBL16162128 | 0.83 | BRAF (0.44) | CYP3A4BRAFCYP2C9 | |
| SCHEMBL16162083 | 0.83 | BRAF (0.43) | CYP3A4MAP3K20BRAFCYP2C9 | |
| SCHEMBL16161908 | 0.83 | BRAF (0.45) | CYP3A4BRAFCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |