Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161915 | 0.99 | BRAF (0.49) | BRAFERN1KITKDM4EMEN1 | |
| SCHEMBL16162088 | 0.92 | BRAF (0.45) | BRAFALOX5APFEN1ALDH1A1LMNA | |
| SCHEMBL16161966 | 0.86 | BRAF (0.63) | BRAFERN1 | |
| SCHEMBL16162013 | 0.85 | BRAF (0.64) | BRAFERN1 | |
| SCHEMBL13249670 | 0.85 | BRAF (0.52) | BRAFERN1KDM4EMEN1KMT2A | |
| SCHEMBL13249671 | 0.84 | BRAF (0.53) | BRAFERN1KITKDM4EMEN1 | |
| SCHEMBL16162131 | 0.84 | BRAF (0.44) | BRAF | |
| SCHEMBL16162152 | 0.82 | BRAF (0.47) | BRAFPIK3C3 | |
| SCHEMBL16162151 | 0.82 | CYP2D6 (0.43) | BRAFERN1 | |
| SCHEMBL16161898 | 0.81 | CYP2C9 (0.46) | BRAFERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |