Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161910 | 0.86 | BRAF (0.51) | BRAFCYP2C9 | |
| SCHEMBL16162082 | 0.85 | BRAF (0.62) | BRAF | |
| SCHEMBL16162151 | 0.85 | CYP2D6 (0.43) | BRAFCYP2C9 | |
| SCHEMBL287849 | 0.84 | BRAF (0.51) | BRAF | |
| SCHEMBL16161898 | 0.84 | CYP2C9 (0.46) | BRAFCYP2C9 | |
| SCHEMBL16162128 | 0.84 | BRAF (0.44) | BRAFCYP2C9 | |
| SCHEMBL16161915 | 0.83 | BRAF (0.49) | BRAFPIK3C3 | |
| SCHEMBL16162131 | 0.83 | BRAF (0.44) | BRAF | |
| SCHEMBL16162136 | 0.83 | CYP2C19 (0.40) | BRAFPIK3C3CYP2C9 | |
| SCHEMBL16162085 | 0.83 | CYP2C19 (0.44) | BRAFPIK3C3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |