Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161898 | 0.94 | CYP2C9 (0.46) | CYP2C19CYP2C9BRAFAXL | |
| SCHEMBL16162128 | 0.90 | BRAF (0.44) | CYP2C19CYP2C9BRAFPIK3CAPIK3R1 | |
| SCHEMBL16162106 | 0.87 | CYP3A4 (0.47) | CYP2C19CYP2C9BRAFAXL | |
| SCHEMBL16162146 | 0.86 | BRAF (0.45) | CYP2C19CYP2C9BRAFPIK3CA | |
| SCHEMBL16162151 | 0.86 | CYP2D6 (0.43) | CYP2C9BRAF | |
| SCHEMBL16162155 | 0.85 | BRAF (0.46) | BRAF | |
| SCHEMBL287946 | 0.85 | CYP2C19 (0.42) | CYP2C19CYP2C9BRAFPIK3CAPIK3R1 | |
| SCHEMBL16162081 | 0.84 | CCR9 (0.39) | CYP2C9BRAF | |
| SCHEMBL16162152 | 0.83 | BRAF (0.47) | CYP2C9BRAFPIK3C3 | |
| SCHEMBL16161908 | 0.83 | BRAF (0.45) | CYP2C19CYP2C9BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170830-B1 | 2-FLUORO-BENZENESULFONAMIDE COMPOUNDS AS Raf KINASE MODULATORS | PLEXXIKON INC (US) | 2014-10-15 | — | — | EP | claimed |