Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | GALR3 | O60755 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13401381 | 0.88 | HPGD (1.00) | HPGDHTTSMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL16166731 | 0.82 | HPGD (0.60) | HPGDHTTSMN1; SMN2GALR3CYP3A4 | |
| SCHEMBL7265907 | 0.82 | SMN1; SMN2 (0.80) | HPGDHTTSMN1; SMN2GALR3CYP3A4 | |
| SCHEMBL2152976 | 0.77 | SMN1; SMN2 (0.72) | HPGDHTTSMN1; SMN2GALR3CYP3A4 | |
| SCHEMBL11245223 | 0.77 | HPGD (0.80) | HPGDHTTSMN1; SMN2GALR3CYP3A4 | |
| SCHEMBL17491765 | 0.75 | SMN1; SMN2 (0.73) | HPGDHTTSMN1; SMN2GALR3CYP3A4 | |
| SCHEMBL6221552 | 0.75 | HPGD (0.74) | HPGDHTTSMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL10348460 | 0.75 | POLB (0.62) | HPGDSMN1; SMN2GALR3CYP3A4CYP2C9 | |
| SCHEMBL3826559 | 0.75 | SMN1; SMN2 (0.54) | HPGDHTTSMN1; SMN2GALR3CYP3A4 | |
| SCHEMBL9475525 | 0.75 | POLB (0.62) | HPGDHTTSMN1; SMN2GALR3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |