Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thiophene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiophene SCHEMBL20482064 | 1.00 | CA1 (0.39) | — | |
| Oxalic Acid SCHEMBL6961961 | 0.89 | DAO (0.32) | — | |
| Oxalic Acid SCHEMBL28318799 | 0.89 | DAO (0.32) | — | |
| Thiophene SCHEMBL28550995 | 0.86 | LCK (0.47) | — | |
| Oxalic Acid SCHEMBL7447158 | 0.86 | DAO (0.31) | — | |
| Acetic Acid SCHEMBL29616843 | 0.86 | LCK (0.47) | — | |
| Oxalic Acid SCHEMBL7447155 | 0.86 | DAO (0.31) | — | |
| Oxalic Acid SCHEMBL6967440 | 0.86 | DAO (0.31) | — | |
| Thiophene SCHEMBL502436 | 0.86 | — | — | |
| Acetic Acid SCHEMBL755556 | 0.86 | LCK (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150251158-A1 | Functionalized Particulate Support Material and Methods of Making and Using the Same | W. R. GRACE & CO.-CONN. (US) | 2015-09-10 | — | — | US | claimed |
| EP-2811983-A1 | FUNCTIONALIZED PARTICULATE SUPPORT MATERIAL AND METHODS OF MAKING AND USING THE SAME | W.R. Grace & CO. - CONN. (US) | 2014-12-17 | — | — | EP | claimed |
| WO-2014043644-A1 | FUNCTIONALIZED PARTICULATE SUPPORT MATERIAL AND METHODS OF MAKING AND USING THE SAME | ALLTECH ASSOCIATES, INC. (US) | 2014-03-20 | — | — | WO | claimed |
| CN-115058743-B | Novel composite electrolyte and method for refining secondary aluminum by low-temperature electrolysis | 昆明理工大学 | 2024-05-24 | — | — | CN | disclosed |
| US-11529610-B2 | Functionalized particulate support material and methods of making and using the same | W.R. GRACE & CO.-CONN. (US) | 2022-12-20 | — | — | US | disclosed |
| CN-113574059-A | Modified ionic liquids containing a cyclic phosphorus moiety | 诺姆斯科技股份有限公司 | 2021-10-29 | — | — | CN | disclosed |
| US-10717866-B2 | Organic-inorganic hybrid composition, and article and optical component including the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2020-07-21 | — | — | US | disclosed |
| EP-2811983-B1 | FUNCTIONALIZED PARTICULATE SUPPORT MATERIAL AND METHODS OF MAKING AND USING THE SAME | GRACE W R & CO (US) | 2019-05-01 | — | — | EP | disclosed |
| US-20180244915-A1 | ORGANIC-INORGANIC HYBRID COMPOSITION, AND ARTICLE AND OPTICAL COMPONENT INCLUDING THE SAME | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2018-08-30 | — | — | US | disclosed |
| CN-103118651-B | For microencapsulation compositions and the method for tissue mineralization | PREMIER DENTAL PRODUCTS COMPNAY (US) | 2016-01-06 | — | — | CN | disclosed |
| US-20150251158-A1 | Functionalized Particulate Support Material and Methods of Making and Using the Same | W. R. GRACE & CO.-CONN. (US) | 2015-09-10 | — | — | US | disclosed |
| US-6555699-B2 | Antitumor and antirheumatic agents, high binding affinity | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-04-29 | — | — | US | disclosed |
| US-20020193616-A1 | 16-ENE-VITAMIN D DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-12-19 | — | — | US | disclosed |
| US-6433200-B1 | ANTITUMOR AND ANTIRHEUMATIC AGENTS, HIGH BINDING AFINITY TO VITAMIN D RECEPTORS AND WEAK HYPERCALCEMIC ACTIVITY | CHUGEI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-08-13 | — | — | US | disclosed |
| US-20020032340-A1 | 16-ene-vitamin D derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-03-14 | — | — | US | disclosed |
| US-6326503-B1 | ANTITUMOR AGENTS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-12-04 | — | — | US | disclosed |
| US-6184398-B1 | ANTITUMOR AGENTS AND TREATMENT OF RHEUMATIC CONDITIONS; HIGH BINDING ABILITY TO VITAMIN D RECEPTORS AND WEAK HYPERCALCEMIC ACTIVITY; E.G.,1,3-DIHYDROXY-20-3-HYDROXY-3-METHYLBUTYLTHIO)-9,10-SECOPREGNA -5,7,10(19),16-TETRAENE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-02-06 | — | — | US | disclosed |
| EP-0947504-A1 | 16-ENE-VITAMIN D DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 1999-10-06 | — | — | EP | disclosed |
| EP-0353753-A1 | Amide compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1990-02-07 | — | — | EP | disclosed |
| US-4036972-A | 2-(N-thienylmethyl-phenylamino)-imidazolines-(2) and salts thereof | BOEHRINGER INGELHEIM GMBH (DT) | 1977-07-19 | — | — | US | disclosed |