Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | APEX1 | P27695 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17787303 | 0.92 | MAPT (0.52) | MAPTKDM4ECRHBPCRHR2HPGD | |
| SCHEMBL29446988 | 0.78 | CA2 (0.62) | MAPTKDM4EHPGDPOLBAPEX1 | |
| SCHEMBL18197 | 0.78 | CA2 (0.62) | MAPTKDM4EHPGDPOLBAPEX1 | |
| SCHEMBL16892543 | 0.77 | KDM4E (0.59) | MAPTKDM4ECRHBPCRHR2HPGD | |
| SCHEMBL18921229 | 0.76 | KDM4E (0.53) | MAPTKDM4ECRHBPCRHR2HPGD | |
| SCHEMBL8820797 | 0.76 | CA2 (0.41) | MAPTKDM4ECRHBPCRHR2HPGD | |
| Phosphine SCHEMBL28067413 | 0.76 | CA2 (0.59) | MAPTKDM4EHPGDPOLBAPEX1 | |
| Ammonia Solution, Strong SCHEMBL28322857 | 0.76 | CA2 (0.59) | MAPTKDM4EHPGDPOLBAPEX1 | |
| SCHEMBL7806601 | 0.76 | CA2 (0.59) | MAPTKDM4EHPGDPOLBAPEX1 | |
| Methane SCHEMBL11062496 | 0.76 | CA2 (0.59) | MAPTKDM4EHPGDPOLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2984098-A2 | DEUTERATED NUCLEOSIDE PRODRUGS USEFUL FOR TREATING HCV | Achillion Pharmaceuticals, Inc. (US) | 2016-02-17 | — | — | EP | disclosed |
| WO-2014169280-A2 | DEUTERATED NUCLEOSIDE PRODRUGS USEFUL FOR TREATING HCV | ACHILLION PHARMACEUTICALS, INC. (US) | 2014-10-16 | — | — | WO | disclosed |