Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | ALKBH2 | Q6NS38 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | ALKBH1 | Q13686 | 3/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16167213 | 0.81 | L3MBTL1 (0.39) | L3MBTL1ACHEHSD17B10ADORA2B | |
| SCHEMBL28791760 | 0.78 | L3MBTL1 (0.59) | L3MBTL1ACHEALKBH2HPGDSHSD17B10 | |
| SCHEMBL28787205 | 0.77 | L3MBTL1 (0.57) | L3MBTL1ACHEALKBH2HPGDSHSD17B10 | |
| SCHEMBL1061889 | 0.76 | L3MBTL1 (0.49) | L3MBTL1ALKBH2HPGDSHSD17B10PLA2G4A | |
| SCHEMBL553834 | 0.74 | L3MBTL1 (0.73) | L3MBTL1ACHEALKBH2HPGDSHSD17B10 | |
| SCHEMBL31681673 | 0.74 | L3MBTL1 (0.67) | L3MBTL1ACHEALKBH2HPGDSHSD17B10 | |
| Hydrochloric Acid SCHEMBL4758885 | 0.73 | L3MBTL1 (0.71) | L3MBTL1ACHEALKBH2HPGDSHSD17B10 | |
| SCHEMBL29954606 | 0.72 | L3MBTL1 (0.65) | L3MBTL1ACHEALKBH2HPGDSHSD17B10 | |
| SCHEMBL31286462 | 0.71 | L3MBTL1 (0.69) | L3MBTL1ACHEALKBH2HPGDSHSD17B10 | |
| SCHEMBL4240582 | 0.71 | L3MBTL1 (1.00) | L3MBTL1ACHEALKBH2HPGDSHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2984091-A1 | DIHYDROPYRIDO PYRIMIDINE COMPOUNDS AS AUTOTAXIN INHIBITORS | Eli Lilly and Company (US) | 2016-02-17 | — | — | EP | disclosed |
| WO-2014168824-A1 | DIHYDROPYRIDO PYRIMIDINE COMPOUNDS AS AUTOTAXIN INHIBITORS | ELI LILLY AND COMPANY (US) | 2014-10-16 | — | — | WO | disclosed |