Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.44 |
| ▸ | THRA | P10827 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852309 | 0.92 | THRB (0.56) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL19677580 | 0.80 | THRB (0.48) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL19677576 | 0.79 | THRB (0.47) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL13886709 | 0.78 | THRB (0.53) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL25819213 | 0.77 | THRB (0.70) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL19677590 | 0.76 | THRB (0.55) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL19695859 | 0.75 | THRB (0.58) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL19677592 | 0.75 | THRB (0.54) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL13949709 | 0.73 | THRB (0.77) | THRBTHRAPPARGRXRAITGB3 | |
| SCHEMBL1526094 | 0.73 | THRB (0.68) | THRBTHRAPPARGRXRAITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859539-B2 | Compositions of dual thyrointegrin antagonists and use in vascular-associated disorders | VASCULAR VISION PHARMACEUTICAL COMPANY (US) | 2014-10-14 | — | — | US | disclosed |