Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 5/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16167691 | 0.86 | EGFR (0.70) | EGFRERBB2 | |
| SCHEMBL16075714 | 0.83 | EGFR (0.76) | EGFRERBB2 | |
| SCHEMBL30264759 | 0.82 | PIK3CD (0.54) | EGFRERBB2PDE4APDE4BPDE4C | |
| SCHEMBL29465791 | 0.82 | PIK3CD (0.54) | EGFRERBB2PDE4APDE4BPDE4C | |
| SCHEMBL2453138 | 0.82 | PIK3CD (0.54) | EGFRERBB2PDE4APDE4BPDE4C | |
| SCHEMBL29465790 | 0.82 | PIK3CD (0.54) | EGFRERBB2PDE4APDE4BPDE4C | |
| SCHEMBL665187 | 0.82 | PIK3CD (0.54) | EGFRERBB2PDE4APDE4BPDE4C | |
| SCHEMBL30264524 | 0.81 | EGFR (0.55) | EGFRERBB2PDE4APDE4BPDE4C | |
| SCHEMBL30264767 | 0.81 | PIK3CD (0.53) | EGFRERBB2PDE4APDE4BPDE4C | |
| SCHEMBL4799156 | 0.80 | EGFR (0.73) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859767-B2 | Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used therein | HANMI SCIENCE CO., LTD (KR) | 2014-10-14 | — | — | US | disclosed |