Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 12/20 | 0.66 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6183340 | 0.84 | EGFR (0.61) | KITEGFRKDM4ELMNAHPGD | |
| SCHEMBL16167691 | 0.80 | EGFR (0.70) | EGFR | |
| SCHEMBL16134405 | 0.80 | KIT (1.00) | KIT | |
| SCHEMBL15911649 | 0.79 | EGFR (0.71) | EGFRLCK | |
| SCHEMBL16167689 | 0.79 | EGFR (0.53) | KITEGFR | |
| SCHEMBL14506813 | 0.78 | ENPP1 (0.56) | KITEGFR | |
| SCHEMBL31193365 | 0.78 | ENPP1 (0.56) | KITEGFR | |
| SCHEMBL29972027 | 0.78 | KIT (0.52) | KITIRAK1IRAK4EGFRKDM4E | |
| Hydrochloric Acid SCHEMBL23355322 | 0.77 | ENPP1 (0.55) | KITEGFR | |
| SCHEMBL14001701 | 0.76 | EGFR (0.73) | KITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859767-B2 | Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used therein | HANMI SCIENCE CO., LTD (KR) | 2014-10-14 | — | — | US | disclosed |