Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12957756 | 0.87 | NQO2 (0.48) | L3MBTL1POLBNQO2MAPTNPSR1 | |
| SCHEMBL3297985 | 0.87 | GRIN2D (0.45) | L3MBTL1POLBNQO2MAPTNPSR1 | |
| SCHEMBL20836401 | 0.87 | MAPT (0.50) | L3MBTL1POLBNQO2MAPTNPSR1 | |
| SCHEMBL31483694 | 0.87 | MAPT (0.50) | L3MBTL1POLBNQO2MAPTNPSR1 | |
| SCHEMBL5859293 | 0.87 | TSHR (0.47) | L3MBTL1POLBNQO2MAPTNPSR1 | |
| SCHEMBL13564409 | 0.84 | NQO2 (0.43) | L3MBTL1POLBNQO2MAPTNPSR1 | |
| SCHEMBL369991 | 0.83 | POLB (0.67) | L3MBTL1POLBMAPTNPSR1PRKDC | |
| SCHEMBL29878552 | 0.83 | POLB (0.67) | L3MBTL1POLBMAPTNPSR1PRKDC | |
| SCHEMBL24769695 | 0.83 | NQO2 (0.42) | L3MBTL1POLBNQO2MAPTNPSR1 | |
| SCHEMBL15031974 | 0.82 | MAPT (0.50) | L3MBTL1POLBNQO2MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2803659-B1 | Method for synthesising 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile and use for synthesising ivabradine and the added salts thereof with a pharmaceutically acceptable acid | SERVIER LAB (FR) | 2017-01-04 | — | — | EP | disclosed |
| US-8859763-B1 | Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | LES LABORATOIRES SERVIER (FR) | 2014-10-14 | — | — | US | disclosed |