Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 6/20 | 0.40 |
| ▸ | CPT2 | P23786 | 2/20 | 0.38 |
| ▸ | CPT1A | P50416 | 2/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800883 | 0.91 | MAPK14 (0.40) | AURKABTKMAPK14CD274PDCD1 | |
| SCHEMBL18800573 | 0.90 | MAPK14 (0.46) | BTKMAPK14FFAR1 | |
| SCHEMBL12874721 | 0.90 | AURKA (0.39) | AURKAAURKBBTKCPT2CPT1A | |
| SCHEMBL18800622 | 0.89 | GRM2 (0.39) | BTKMAPK14CD274PDCD1 | |
| SCHEMBL16168176 | 0.87 | BTK (0.46) | AURKAAURKBBTKCPT2CPT1A | |
| SCHEMBL18800882 | 0.86 | BTK (0.42) | BTKTNK2 | |
| SCHEMBL18800574 | 0.85 | BTK (0.42) | BTKTNK2 | |
| SCHEMBL18800641 | 0.85 | BTK (0.42) | BTKTNK2 | |
| SCHEMBL18800866 | 0.85 | FFAR1 (0.44) | FFAR1 | |
| SCHEMBL18800748 | 0.84 | BTK (0.42) | BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |
| EP-2789615-A1 | Azaindazoles as Btk kinase modulators and use thereof | Bristol-Myers Squibb Company (US) | 2014-10-15 | — | — | EP | disclosed |