Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 16/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800882 | 0.88 | BTK (0.42) | — | |
| SCHEMBL18800574 | 0.88 | BTK (0.42) | PLA2G10PLA2G2A | |
| SCHEMBL18800641 | 0.88 | BTK (0.42) | — | |
| SCHEMBL18800748 | 0.85 | BTK (0.42) | — | |
| SCHEMBL16168189 | 0.85 | AURKA (0.40) | FFAR1 | |
| SCHEMBL18800573 | 0.84 | MAPK14 (0.46) | FFAR1 | |
| SCHEMBL18800755 | 0.84 | TNK2 (0.50) | — | |
| SCHEMBL18800492 | 0.83 | BTK (0.48) | — | |
| SCHEMBL18800775 | 0.82 | TNK2 (0.48) | — | |
| SCHEMBL16168176 | 0.82 | BTK (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |