Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ILK | Q13418 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748778 | 0.88 | CRHR1 (0.42) | CRHR1TP53POLBMAPTKDM4E | |
| SCHEMBL3754961 | 0.74 | CRHR1 (0.47) | CRHR1MAPTL3MBTL1 | |
| SCHEMBL16168785 | 0.72 | CRHR1 (0.44) | CRHR1MAPTL3MBTL1 | |
| SCHEMBL3751171 | 0.69 | CRHR1 (0.55) | CRHR1MAPTALDH1A1 | |
| SCHEMBL3758025 | 0.64 | CRHR1 (0.58) | CRHR1MAPTALDH1A1 | |
| SCHEMBL3734143 | 0.62 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL3285946 | 0.62 | KDM4E (0.47) | MAPTKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL3721355 | 0.62 | CRHR1 (0.66) | CRHR1ALDH1A1HTTRXFP1 | |
| SCHEMBL3752027 | 0.61 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL16008419 | 0.61 | ABL1 (0.54) | MAPTKDM4EPLA2G2AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-B1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL (JP) | 2014-10-15 | — | — | EP | disclosed |