Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 18/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753841 | 0.94 | CRHR1 (0.54) | CRHR1ADORA3MAOBADORA1 | |
| SCHEMBL4091510 | 0.89 | CRHR1 (0.55) | CRHR1ADORA3MAOBADORA1 | |
| SCHEMBL3746111 | 0.82 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL3753616 | 0.81 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL3756461 | 0.81 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL3760362 | 0.80 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL3752944 | 0.78 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL3667088 | 0.78 | CRHR1 (0.62) | CRHR1MAOB | |
| SCHEMBL3730355 | 0.76 | CRHR1 (0.76) | CRHR1 | |
| SCHEMBL3724782 | 0.76 | CRHR1 (0.68) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-B1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL (JP) | 2014-10-15 | — | — | EP | disclosed |