Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13764104 | 0.84 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL3666226 | 0.84 | CRHR1 (0.77) | CRHR1 | |
| SCHEMBL3758810 | 0.84 | CRHR1 (0.62) | CRHR1 | |
| SCHEMBL3750756 | 0.83 | CRHR1 (0.76) | CRHR1 | |
| SCHEMBL3758851 | 0.82 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL3760048 | 0.82 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL3750583 | 0.82 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL3760290 | 0.82 | CRHR1 (0.77) | CRHR1 | |
| SCHEMBL3765425 | 0.82 | CRHR1 (0.67) | CRHR1 | |
| SCHEMBL3748540 | 0.81 | CRHR1 (0.73) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240485-B1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL (JP) | 2014-10-15 | — | — | EP | disclosed |