Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 5/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 5/20 | 0.50 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.50 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.50 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.42 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23211167 | 0.77 | GRIA1 (0.47) | GRIA1GRIA2GRIA4GRIK5GRIA3 | |
| SCHEMBL7235118 | 0.77 | GRIA1 (0.47) | GRIA1GRIA2GRIA4GRIK5GRIA3 | |
| SCHEMBL22748998 | 0.73 | GRIA1 (0.57) | GRIA1GRIA2GRIA4GRIK5GRIA3 | |
| SCHEMBL11708335 | 0.73 | GRIA1 (0.64) | GRIA1GRIA2GRIA4GRIK5GRIA3 | |
| SCHEMBL7233498 | 0.70 | GRIA1 (0.58) | GRIA1GRIA2GRIA4GRIK5GRIA3 | |
| SCHEMBL10456669 | 0.70 | GRIA1 (0.53) | GRIA1GRIA2GRIA4GRIK5TSHR | |
| SCHEMBL16167009 | 0.69 | MAPT (0.43) | GRIA1GRIA2GRIA4GRIK5GRIA3 | |
| SCHEMBL23211205 | 0.68 | KMT2A (0.59) | GRIA1GRIA2GRIA4GRIK5GRIA3 | |
| SCHEMBL5846928 | 0.67 | HPGD (0.60) | GRIA1GRIA2GRIA4GRIK5MAPT | |
| SCHEMBL14530599 | 0.67 | GRIA1 (0.41) | GRIA1GRIA2GRIA4GRIK5GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014168986-A1 | THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS | BROWN DENNIS M (US) | 2014-10-16 | — | — | WO | disclosed |