SCHEMBL16175604

SCHEMBL16175604

Oc1cnc(OC2CCC(F)(F)CC2)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IP6K1 Q92551 19/20 0.42
SCN9A Q15858 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16175151 0.86 MAPK1 (0.42) IP6K1SCN9A
SCHEMBL365763 0.83 SCN9A (0.43) IP6K1SCN9A
SCHEMBL364379 0.79 LRRK2 (0.38) IP6K1SCN9A
SCHEMBL16175423 0.77 SSTR4 (0.41)
SCHEMBL16175117 0.75 AAK1 (0.39) IP6K1
SCHEMBL363025 0.71 SCN9A (0.36) SCN9A
SCHEMBL20265434 0.70 MALT1 (0.39) IP6K1SCN9A
SCHEMBL15093793 0.68 SCN9A (0.42) SCN9A
SCHEMBL16858563 0.68 CYP1A2 (0.36) IP6K1SCN9A
SCHEMBL15599224 0.67 SSTR4 (0.41) IP6K1SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593432-B1 N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS PFIZER LTD (GB) 2014-10-22 EP disclosed